Hydroxylated Polymethoxy Flavones Solid Dispersion in Treatment of Periodontitis
Status:
Not yet recruiting
Trial end date:
2022-11-10
Target enrollment:
Participant gender:
Summary
Periodontitis is a serious gum infection that damages the soft tissue and, without treatment,
can destroy the bone that supports your teeth.
Hydroxylated poly methoxy flavones are a combination of naturally occurring flavonoids
extracted from the orange peel and exert anti-inflammatory, antibacterial, and antifungal
activity however, this extract is poorly soluble and poorly absorbable. In this work, this
extract was formulated as a solid dispersion formulation to enhance its biological activity
and then incorporated into a gel base and used in the treatment of periodontitis after
clinical debridement.