Hydroxylated Polymethoxy Flavones Solid Dispersion in Treatment of Periodontitis

• Status: Not yet recruiting
• Trial end date: 2022-11-10
• Target enrollment: 0
• Participant gender: All

Summary

Periodontitis is a serious gum infection that damages the soft tissue and, without treatment, can destroy the bone that supports your teeth.

Hydroxylated poly methoxy flavones are a combination of naturally occurring flavonoids extracted from the orange peel and exert anti-inflammatory, antibacterial, and antifungal activity however, this extract is poorly soluble and poorly absorbable. In this work, this extract was formulated as a solid dispersion formulation to enhance its biological activity and then incorporated into a gel base and used in the treatment of periodontitis after clinical debridement.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Assiut University

Criteria

Inclusion Criteria:

• Patients with periodontitis stage I-II

• free from any systemic disorders.

• no mobility - non-smokers - no parafunctional habits.

• Each patient with minimum three periodontitis sites ( split-mouth study)

Exclusion Criteria:

• Smokers.

• patients with diabetes, and hypertension.