Hydroxyurea With or Without Imatinib Mesylate in Treating Patients With Recurrent or Progressive Meningioma

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy, such as hydroxyurea, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Imatinib mesylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether hydroxyurea is more effective when given alone or together with imatinib mesylate in treating patients with meningioma.

PURPOSE: This randomized phase II trial is studying how well hydroxyurea works compared with giving hydroxyurea together with imatinib mesylate in treating patients with recurrent or progressive meningioma.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Istituto Scientifico H. San Raffaele
• Treatments: Hydroxyurea; Imatinib Mesylate

Criteria

DISEASE CHARACTERISTICS:

• Diagnosed with meningioma

• WHO grade I-III

• Recurrent or progressive disease after prior surgery and radiotherapy, or radiosurgery

• Not amenable to further surgery

• No optic nerve sheet tumor and neurofibromatosis type II

• No known brain metastasis

PATIENT CHARACTERISTICS:

• WHO performance status 0-2

• ANC > 1,500/mm^3

• Platelet count > 100,000/mm^3

• Hemoglobin ≥ 9 mg/dL (transfusion allowed)

• Total bilirubin < 1.5 times upper limit of normal (ULN)

• SGOT and SGPT < 2.5 times ULN

• Creatinine < 1.5 times ULN

• Negative pregnancy test

• Fertile patients must use effective barrier method contraception during and for up to 3 months after completion of study therapy

• No second malignancy

• No known chronic liver disease (i.e., active hepatitis, cirrhosis)

• No known HIV infection

• No significant history of non-compliance to medical regimens or inability to grant reliable informed consent

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics

• No concurrent enzyme-inducing anti-epileptic drugs

• No concurrent therapeutic anticoagulation with warfarin (e.g., Coumadin®)

• Low-molecular weight heparin (e.g., Lovenox) or heparin allowed

• Mini-dose Coumadin® (e.g., 1 mg QD) allowed for prophylaxis of central venous catheter thrombosis, at the discretion of the treating physician

• No concurrent acetaminophen (Efferalgan®, Tachipirina®) allowed during imatinib mesylate administration

• No other concurrent anticancer agents, including chemotherapy or biological agents

• No other concurrent investigational drugs