Hylenex-Assisted Resuscitation in Kenya (HARK) Trial for the Management of Dehydration
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
One of the leading health issues among patients, particularly children, presenting for care
in low- and middle-income countries is dehydration. When oral rehydration is not sufficient
or is clinically inappropriate, rehydration often occurs intravenously. An alternative to
intravenous rehydration is subcutaneous infusion and - with or without hyaluronidase enzyme
(or Hylenex) - has been shown in several robust trials in high-income countries to be as
effective and even safer than intravenous infusion. In this study in western Kenya, the
investigators propose a first-ever randomized controlled trial to evaluate whether
hyaluronidase-facilitated subcutaneous infusion can be as effective and safe as IV therapy
among moderate-to-severely dehydrated patients in low- and middle-income countries.