Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting
Status:
Completed
Trial end date:
2021-01-09
Target enrollment:
Participant gender:
Summary
Randomized, double-blinded, three arm study in adult patients undergoing first time coronary
artery bypass grafting (CABG) surgery with median sternotomy. The investigators will examine
the effects of three fentanyl dosing schemes (high-dose bolus, low-dose bolus, continuous
dose) on the area of hyperalgesia and allodynia at 24 and 48h as well as on persisting pain
at 3, 6, and 12 months. Additionally, the investigators will measure fentanyl concentrations
throughout anesthesia.