Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms
Status:
Not yet recruiting
Trial end date:
2026-12-01
Target enrollment:
Participant gender:
Summary
Persistent post-concussive symptoms (PPCS) are a source of significant burden among a subset
of patients with concussion with prevalence rates previously reported between 11 - 82% based
on timing of assessment, diagnostic criteria, or population under study.
Examples of persistent post-concussion symptoms include balance problems, headaches, fatigue,
poor concentration, forgetfulness, anxiety, irritability, and sleep disturbance. Few proposed
therapies have proved successful in the management of persistent post-concussion symptoms
following mild traumatic brain injury.
We explore hyperbaric oxygen administered in a randomized sham-controlled clinical trial as
an effective and tolerable treatment in improving neuropsychological status among adult
patients with persistent post-concussive symptoms.
The overall hypothesis to be evaluated is that hyperbaric oxygen improves neuropsychological
status and a serum concussion biomarker associated with PPCS.
Phase:
Phase 2
Details
Lead Sponsor:
Essentia Health
Collaborators:
Dakota Medical Foundation State of North Dakota The Swanson Foundation University of North Dakota