Hyperbaric Versus Normobaric Oxygen Therapy for COVID-19 Patients
Status:
Recruiting
Trial end date:
2022-08-01
Target enrollment:
Participant gender:
Summary
At least 1 in 6 COVID-19 patients admitted to hospital to receive extra oxygen will die of
complications. In patients with COVID-19, invasive treatment such as mechanical ventilation
(e.g. breathing with a machine) is associated with a 50% increased risk of death. Invasive
treatments use a lot of healthcare resources in intensive care units and may lead to further
deaths if patients do not have access to care.
The investigators aim to improve outcomes for COVID-19 patients by implementing hyperbaric
oxygen therapy (HBOT). HBOT allows patients to breathe 100% oxygen in a special chamber at a
pressure higher than sea level. It is approved by Health Canada for 14 conditions. HBOT is
safe when administered by experienced teams.
There are two main causes of death in severe COVID-19 respiratory infections: (i) a decreased
diffusion of oxygen from the lungs to the blood and (ii) an increased inflammatory response
(also called a "cytokine storm"). HBOT leads to increased oxygen level in blood, has strong
anti-inflammatory effects, and may destroy the virus responsible for COVID-19 disease. The
initial experience with HBOT and COVID-19 from China, France and the United States is
promising in that it prevents further worsening of the condition and need for intensive care.
The investigators propose to test the effectiveness of HBOT for COVID-19 patients who are
admitted to hospital to receive extra oxygen. Using the most rigorous and innovative research
methods, this Canadian-led international study will operate at 5 centers across 3 countries
(Canada: Ottawa, Toronto, Edmonton; Switzerland: Geneva; UK: Rugby/London). The investigators
anticipate that when treated by HBOT, COVID-19 patients needing extra oxygen to breathe will
see significant health improvements as well as a decrease in complications, inflammation in
the blood, need for invasive care, death, and cost of care.