Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

• Status: Recruiting
• Trial end date: 2026-10-26
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to develop and evaluate the usefulness of hyperpolarized (HP) 129Xe gas MRI for regional assessment of pulmonary function.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mario Castro, MD, MPH

Criteria

Inclusion Criteria:

Healthy Volunteers:

• Subject has no diagnosed pulmonary conditions

• Ability to read and understand English or Spanish

Subjects with Lung Disease:

• Subject has a diagnosis of pulmonary dysfunction made by a physician

• No acute worsening of pulmonary function in the past 30 days

• Ability to read and understand English or Spanish

Exclusion Criteria:

• MRI is contraindicated based on responses to MRI screening questionnaire

• Subject is pregnant or lactating

• Subject does not fit into 129Xe vest coil used for MRI

• Subject cannot hold his/her breath for 15-16 seconds

• Subject deemed unlikely to be able to comply with instructions during imaging

• Oxygen saturation <88% on room air or with supplemental oxygen

• Cognitive deficits that preclude ability to provide consent

• Institutionalization