Hyperpolarized 129Xe MRI of Survivors of COVID-19

• Status: Recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate pulmonary function of patients recovering from mild, moderate, and severe COVID-19 disease using hyperpolarized 129Xe MRI.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Kansas Medical Center

Criteria

Inclusion Criteria:

• Oxygenation saturation of ≥88% at rest by study staff within 48 hours prior to study entry.

• The participant has a previous diagnosis of COVID-19 confirmed by COVID-19 PCR or antibody testing and is being seen for outpatient follow-up.

• Subject is at least 10 days post-symptom-onset and do not have a fever (<99.5°).

• Ability to read and understand English or Spanish

Exclusion Criteria:

• Subject is less than 18 years old

• MRI is contraindicated based on responses to MRI screening questionnaire

• Subject is pregnant or lactating

• Subject does not fit into 129Xe vest coil used for MRI

• Subject cannot hold his/her breath for 15-16 seconds

• Subject deemed unlikely to be able to comply with instructions during imaging

• Oxygen saturation <88% on room air or with supplemental oxygen

• Cognitive deficits that preclude ability to provide consent

• Institutionalization