Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury
Status:
Recruiting
Trial end date:
2026-11-26
Target enrollment:
Participant gender:
Summary
The purpose of this study is to examine the safety and feasibility of using hyperpolarized
metabolic MRI to study early brain metabolism changes in subjects presenting with head injury
and suspected non-penetrating traumatic brain injury (TBI). This study will also compare HP
pyruvate MRI-derived metrics in TBI patients with healthy subjects as well as Subarachnoid
hemorrhage (SAH) patients to better understand if metabolic Magnetic resonance imaging scan
(MRI) can improve our ability to diagnose a TBI.
The FDA is allowing the use of hyperpolarized [1-13C] pyruvate (HP 13C-pyruvate) in this
study.
Up to 15 patients (5 with TBI, 5 with SAH, and 5 healthy volunteers) may take part in this
study at the University of Maryland, Baltimore (UMB).