Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial)
Status:
Recruiting
Trial end date:
2022-10-31
Target enrollment:
Participant gender:
Summary
The aim of this study is to determine if lowering blood pressure using FDA approved
medication (antihypertensive drugs) alters brain pulsatility and reduces brain amyloid beta
protein accumulation in older adults. Amyloid beta protein is high in the brain of older
adults with Alzheimer's disease. Hypertension may increase brain amyloid beta protein
accumulation and affect memory and thinking ability in older adults. However, whether
lowering blood pressure reduces brain amyloid beta protein and improves brain function is
inconclusive.
The investigators hypothesize that treating high blood pressure alters brain pulsatility,
which in turn reduces brain amyloid beta protein accumulation and improves brain structure
and function.