Hyperthermia With Chemoradiotherapy in Rectal Cancer
Status:
RECRUITING
Trial end date:
2037-03-01
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to evaluate the efficacy of deep regional hyperthermia in the context of radiochemotherapy followed by consolidation chemotherapy in locally advanced rectal cancer.
Questions it aims to answer are:
* Can surgery be avoided if the tumor completely regresses?
* How high is the Local re-growth rate
* Is the treatment safe?
* Assessment of the Quality of life
* Rate of sphincter-sparing surgery
* Pathological staging, tumor downstaging
* Assessment of continence during the course of therapy
Participants will:
Undergo radiochemotherapy with or without addition of hyperthermia (50:50 randomisation) followed by standard consolidation chemotherapy. After treatment response evaluation surgery or non-operative management takes place.
Phase:
NA
Details
Lead Sponsor:
University Hospital Tuebingen
Collaborators:
Charite University, Berlin, Germany University Hospital Erlangen
Treatments:
Consolidation Chemotherapy Diathermy Drug Therapy Fluorouracil Folfox protocol Radiotherapy