Hyperthermic Intraperitoneal Oxaliplatin for Peritoneal Malignancies
Status:
Completed
Trial end date:
2011-09-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, and fluorouracil,
work in different ways to stop the growth of tumor cells, either by killing the cells or by
stopping them from dividing. Hyperthermia therapy kills tumor cells by heating them to
several degrees above normal body temperature. Peritoneal infusion of heated and nonheated
chemotherapy drugs after surgery may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of hyperthermic
intraperitoneal oxaliplatin followed by intraperitoneal leucovorin and fluorouracil in
treating patients with peritoneal cancer.