Hypertonic Resuscitation Following Severe Traumatic Brain Injury (TBI)
Status:
Terminated
Trial end date:
2010-01-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine if hypertonic saline with and without dextran can
improve neurologic outcomes in victims of severe traumatic brain injury (TBI).
Injury and lost blood from trauma can cause your body to go into shock (low blood pressure
related to blood loss). This decreased blood flow can lead to organ damage. In order to
restore the blood pressure and blood flow, the medics give fluids into the patients' veins as
soon as possible. This is called "resuscitation". The fluid most commonly used is "isotonic"
or one that is the same salt concentration as the blood. The investigators are trying to
determine if infusing a "hypertonic" fluid or one more concentrated than the blood can
increase the blood pressure and restore blood flow more efficiently. The hypertonic fluids
they are using are called hypertonic saline with dextran (HSD) and hypertonic saline (no
dextran). Hypertonic saline is a salt solution that is slightly more concentrated than blood.
Dextran is a sugar solution.
Phase:
Phase 3
Details
Lead Sponsor:
University of Washington
Collaborators:
Canadian Department of National Defense Canadian Institutes of Health Research (CIHR) Heart and Stroke Foundation of Canada National Heart, Lung, and Blood Institute (NHLBI) National Institute of Neurological Disorders and Stroke (NINDS) U.S. Army Medical Research and Development Command U.S. Army Medical Research and Materiel Command