Hypertonic Saline 75% vs Mannitol 20%

• Status: Completed
• Trial end date: 2007-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the effect of Hypertonic Saline 7.5% vs Mannitol 20% on brain bulk (using a 4 point scale), intracranial pressure (subdural catheter)and the changes on serum and urinary Na, K and Osmolarity during elective craniotomy for brain tumor resection.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lawson Health Research Institute
• Treatments: Mannitol

Criteria

Inclusion Criteria:

• ASA physical status I - 3.

• Age >18 years.

• Scheduled for elective craniotomies for supratentorial brain tumour resection.

• Written informed consent.

Exclusion Criteria:

• Within the past six months, a history of unstable angina pectoris and/or having a myocardial infarction.

• Electrocardiogram abnormalities indicating severe ischemia.

• Congestive heart failure.

• Glasgow coma sore < 9

• Refusal to participate or refusal to agree to randomization.

• Known renal failure

• Known poorly controlled diabetes.