Hypertonic Saline Solution to Prevent Acute Kidney Injury After Heart Transplantation

• Status: Not yet recruiting
• Trial end date: 2025-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to evaluate if hypertonic saline solution can prevent or attenuate acute kidney injury after heart transplantation in the early postoperative phase.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Fernando Bacal
• Treatments: Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Hospitalized patients submitted to orthotopic heart transplantation (HT)

Exclusion Criteria:

• Requirement of renal replacement therapy before HT

• Requirement of extracorporeal membrane oxygenation (ECMO) before HT

• Double transplant (e.g. heart-kidney or heart-lung)

• Hypernatremia (Na ≥ 145)

• Moderate or severe hyponatremia (Na ≤ 120)