Hypnotic Medications and Memory: Effect of Drug Exposure During the Night

• Status: Completed
• Trial end date: 2011-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effect of two hypnotic medications, zolpidem extended release and zaleplon, on memory. It is expected that a hypnotic with shorter drug duration will allow greater memory consolidation than a hypnotic with longer drug duration.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: St. Luke's Hospital, Chesterfield, Missouri
• Collaborator: American Academy of Sleep Medicine
• Treatments: Hypnotics and Sedatives; Zaleplon; Zolpidem

Criteria

Inclusion Criteria:

• 18 to 50 years of age

• no sleep complaints or problems

• good sleep quality per questionnaire

• sufficient time in bed each night

Exclusion Criteria:

• any clinically significant unstable medical condition

• recent psychiatric disorder

• prior diagnosis or symptoms of a sleep disorder

• recent history of substance abuse

• recent use of prescription hypnotic medication or over-the-counter sleep aid

• recent use of psychotropic medication

• history of adverse reaction to benzodiazepines

• body mass index > 36

• currently pregnant or nursing

• currently working rotating or night shift

• consumption of > 700 mg per day of xanthine-containing food or beverages

• consumption of > 14 units of alcohol per week

• smoke > 1 pack of cigarettes per day, use of chewing tobacco more than 3 times per day, or unable to refrain from smoking or chewing without distress or discomfort while in the sleep laboratory