Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q5
Status:
Withdrawn
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
When a patient with Type 1 diabetes exercises, he or she is more prone to low blood sugar, or
hypoglycemia. It is known that antecedent exercise can blunt defense responses, called
counterregulatory responses to subsequent hypoglycemia in Type 1 DM, causing him or her to be
vulnerable to another bout of hypoglycemia. Epinephrine is one of the important hormones in
the defense of blood glucose during both exercise and hypoglycemia. We will test the
hypothesis that antecedent exercise will blunt the metabolic, neuroendocrine and
cardiovascular effects of subsequent epinephrine infusion in Type 1 DM.
Phase:
N/A
Details
Lead Sponsor:
Vanderbilt University Vanderbilt University Medical Center