Low testosterone production, known clinically as hypogonadism, appears to be common
complication of type 2 diabetes, affecting one in three diabetic men. Hypogonadism is known
to be associated with decreased muscle mass, increased fat mass, increased inflammation and
decreased fertility. In this grant, the investigators propose to study the effects of having
low testosterone on 1) insulin sensitivity, the ability of the body to handle glucose 2) fat
and muscle mass at specific areas of the body 3) expression of mediators of inflammation in
the blood 4) semen quality. This study will compare diabetic men (with or without
hypogonadism). This study will also evaluate the effect of treatment with clomiphene (a drug
that increases testosterone and sperm production) or testosterone in men with diabetes and
hypogonadism. The investigators hope that this project will help us understand the state of
hypogonadism in young type 2 diabetic men who are in their peak fertility years and give us
insights into treatment of this condition. With the rising prevalence of type 2 diabetes in
the young, this project may have implications for public health.