Hypothalamic Obesity Following Craniopharyngioma Surgery: A Pilot Trial of Combined Metformin and Diazoxide Therapy
Status:
Completed
Trial end date:
2008-01-01
Target enrollment:
Participant gender:
Summary
To study the effect of combined diazoxide-metformin therapy on body weight in youth with
hypothalamic obesity following treatment for craniopharyngioma. A secondary objective is to
evaluate changes in insulin resistance (IR), beta-cell function, features of the metabolic
syndrome, muscle metabolism and intramyocellular lipid.
Hypothesis: Treatment with diazoxide and metformin will result in weight loss or slowed
weight gain and improved metabolic profile, compared to pretreatment levels.