Overview

Hypothyroidism, Metabolism and Quality of Life - Focus on QOL, REE, Cognitive Function and Body Composition

Status:
Completed

Trial end date:
2018-05-20

Target enrollment:
0

Participant gender:
All

Summary

This project has the following primary aims: The main objective is to delineate the association between changes in Resting energy expenditure (REE) and QOL in hypothyroid patients before and after one year of L-T4 treatment. To achieve this, the investigators plan to compare newly diagnosed hypothyroid patients soon after diagnosis before L-T4 therapy has been initiated after 6 months and after 1 year of treatment. Primary endpoint is changes in REE compared to changes in QOL Secondary endpoint is changes in cognitive function and changes in body composition before and after one year of treatment and furthermore changes in insulin resistance following changes in body composition and free fatty acids (FFA).

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Herlev Hospital

Criteria

Inclusion Criteria:

- TSH > 10 mU/liter

Exclusion Criteria:

- Serious competing illness

- Pregnancy or planning to become pregnant

- Thyroidectomized patients

- Unable to speak and understand danish