Vitamin D has been shown to impact prognosis in a variety of retrospective and randomized
clinical trials within an intensive care unit (ICU) environment. Despite these findings,
there have been no studies examining the impact of hypovitaminosis D in specialized
neurocritical care units (NCCU). Given the often significant differences in the management of
patients in NCCU and more generalized intensive care units there is a need for further
inquiries into the impact of low vitamin D levels in this specific environment. This study
proposes a randomized, double-blinded, placebo-controlled, single center evaluation of
vitamin D supplementation in the emergent NCCU patient population. The primary outcome will
involve length-of-stay for emergent neurocritical care patients. Various secondary outcomes,
including in-hospital mortality, ICU length-of-stay, Glasgow Outcome Score on discharge,
complications and quality-of-life metrics. Patients will be followed for 6 months
post-discharge.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
University of Utah
Treatments:
Cholecalciferol Ergocalciferols Vitamin D Vitamins