IDEAL Study: Identification of the Determinants of the Efficacy of Arterial Blood Pressure Lowering Drugs
Status:
Completed
Trial end date:
2010-09-01
Target enrollment:
Participant gender:
Summary
The principal scientific objective of the trial is to identify the factors that are
associated with differential blood pressure responses between drugs. This may allow
investigators to produce new hypotheses on the pathophysiology of hypertension and on the
mechanisms of drug action.
These factors can be of different types:
- Environmental factors (sodium or alcohol intake);
- Morphological (height, weight, body mass index, body surface area);
- Initial blood pressure;
- Electrocardiogram (ECG) parameters of left ventricular hypertrophy;
- Biological parameters as the activity level of the renin angiotensin aldosterone system;
- Genetic polymorphisms.