IM Olanzapine Versus Haloperidol or Midazolam

• Status: Terminated
• Trial end date: 2019-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether intramuscular olanzapine is safer (fewer adverse events) and more effective (shorter time to sedation) than conventional haloperidol or midazolam when used in the management of acute agitation in the emergency department.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Hong Kong
• Collaborators: Pamela Youde Nethersole Eastern Hospital; Prince of Wales Hospital, Shatin, Hong Kong; Queen Mary Hospital, Hong Kong; Ruttonjee Hospital; Tuen Mun Hospital; United Christian Hospital
• Treatments: Haloperidol; Haloperidol decanoate; Midazolam; Olanzapine

Criteria

Inclusion Criteria:

• Emergency Department patients, requiring parenteral drug sedation (as determined by an emergency clinician) will be enrolled.

Exclusion Criteria:

• Patients will be excluded if there are

1. known hypersensitivity or contraindication to the study drugs

2. reversible aetiology for agitation (e.g. hypotension, hypoxia, hypoglycaemia)

3. known pregnancy

4. acute alcohol withdrawal

5. patients aged>75 years.