IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium.

• Status: Completed
• Trial end date: 2012-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to test the impact of pharmacological myocardial metabolic support, in the form of intravenous (IV) glucose, insulin and potassium (GIK), for the treatment of patients with threatened or established acute myocardial infarction (AMI).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tufts Medical Center
• Collaborator: National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Symptoms of threatened or established AMI including but not limited to:

1. Chest pain, discomfort, or tightness

2. Arm or shoulder pain

3. Jaw pain

4. Epigastric discomfort

5. Shortness of breath

• 12-lead electrocardiogram (ECG) with two or more contiguous leads with ST elevation greater than 1 mm, ST depression greater than 0.5 mm, T wave inversion or other T wave abnormalities (hyperacute T waves), or left bundle branch block (not known to be old). Identification aided by the acute cardiac ischemia time-insensitive predictive instrument (ACI-TIPI)and thrombolytic predictive instrument (TPI) decision support software (ACI-TIPI >= 75% and TPI detection of suspected STEMI).

Exclusion Criteria:

• End-stage kidney failure requiring dialysis

• Rales present more than halfway up the back

• Unable to comply with the requirements of the study

• Incarcerated

• Known to be pregnant