IN-OFFICE TOOTH BLEACHING WITH 37% CARBAMIDE PEROXIDE
Status:
Completed
Trial end date:
2016-11-01
Target enrollment:
Participant gender:
Summary
Objectives: This study will determine the clinical efficacy of bleaching agent 37% carbamide
peroxide compared to 35% hydrogen peroxide on the change of color scores in anterior superior
teeth, in-office bleaching technique after 7, 14 and 37 days; and the Risk to the tooth
sensitivity before, during and 24 hours after the procedure.
Materials and Methods: Fifty patients will be selected for this single-blind, parallel,
randomized-controlled clinical trial. The whitening treatment with 37% carbamide peroxide or
35% hydrogen peroxide (control) will be carried out in a single application of 45 minutes for
two sessions with a 7-day interval. The sensitivity level will be assessed before, during and
24 hours after the procedure using verbal and analogic visual analogue (VAS) scales. Color
alteration will be assessed by a bleach guide scale 7 days after each session and 30 days
after the last session. Relative risk to sensitivity will be calculated and adjusted by
session; while comparison of overall risk will performed by McNemar's test. Data on the
sensitivity level for both scales will be subjected to the Mann-Whitney tests (α = 0.05). The
color change will be measured with a spectrophotometer using the CIE L * a * b * and the L*,
a * and b * parameter delta data, and ΔE and Δ00, will be individually subjected to two-way
repeated measures ANOVA test to compare the two bleaching techniques at each evaluation time
(α = 0.05).