IRB-HSR# 14145 R,S Methadone: Analgesia and Pharmacokinetics in Adolescents Undergoing Scoliosis Correction
Status:
Completed
Trial end date:
2010-04-01
Target enrollment:
Participant gender:
Summary
This is a pilot study to determine the pharmacokinetics of (R,S) methadone in adolescents. A
total of approximately 15 patients will be required. The purpose is to determine the levels
of R, S methadone at various time intervals after drug administration. Patients will receive
methadone 0.25 mg/kg IV at induction and a standardized anesthetic of remifentanil and
propofol. At the conclusion of surgery (45 minutes prior to the completion), the patients
will receive a loading dose of morphine based on respiratory rate. A morphine PCA will be
utilized for postoperative analgesia. Pharmacokinetic data will be collected in addition to
VAS scores, patient and parental satisfaction with analgesia, and a functional pain
assessment.