IRDye800CW-BBN PET-NIRF Imaging Guiding Surgery in Patients With Lower Grade Glioma
Status:
Unknown status
Trial end date:
2018-12-30
Target enrollment:
Participant gender:
Summary
This is an open-label positron emission tomography/near infrared (PET/NIRF) study to
investigate the imaging navigation performance and evaluation efficacy of dual modality
imaging probe 68Ga-BBN-IRDye800CW in patients with lower grade glioma. A single dose of
40μg/111-148 Mega-Becquerel (MBq) 68Ga-NOTA-BBN and 1.0- or 2.0- mg/ml IRDye800CW-BBN will be
injected intravenously before the operation and intraoperative respectively. Visual and
semiquantitative method will be used to assess the PET images and real-time margins
localization for surgical navigation.
Phase:
Early Phase 1
Details
Lead Sponsor:
Deling Li
Collaborators:
Chinese Academy of Sciences Key laboratory of molecular imaging Chinese Academy of Sciences National Institute for Biomedical Imaging and Bioengineering (NIBIB) Peking Union Medical College Hospital