IV Acetaminophen After Cardiac Surgery

• Status: Not yet recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Double blind double dummy of Intravenous Acetaminophen and oral acetaminophen placebo versus IV placebo versus oral acetaminophen in patients following cardiac surgery. The primary endpoint is development of Delirium during the post-operative stay.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
• Collaborators: McMaster University; Montreal Heart Institute; University of Manitoba
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• subjects > 18 years of age undergoing elective aortocoronary bypass, single valve replacement or single valve and aortocoronary bypass surgery

Exclusion Criteria:

• • Refusal by surgeon for inclusion of the patient

• Requested late extubation by anesthesia or surgeon

• Intra-aortic balloon pump

• Sensitivity to acetaminophen

• Pre-operative cognitive dysfunction

• Psychiatric history with active treatment

• Parkinson's disease

• Alzheimer's disease

• Medication for cognitive decline

• History of recent seizures

• Recent history of alcohol misuse

• Creatinine clearance less than 30 ml/min