IV Acetaminophen for Postoperative Pain Analgesia After Laparoscopic Hysterectomy

• Status: Completed
• Trial end date: 2016-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

The objective of this study is to quantify the change in post-operative pain scores and narcotic requirements in women receiving pre and post-operative IV acetaminophen compared to placebo in women undergoing laparoscopic hysterectomy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Pittsburgh
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• Women aged 18-75

• Ability to read and write in English (our post-operative pain log is only available in English)

• Planning a laparoscopic hysterectomy (includes total laparoscopic hysterectomy, laparoscopic supracervical hysterectomy, laparoscopically assisted vaginal hysterectomy, with or without salpingooophorectomy)

Exclusion Criteria:

• Answering yes to any of the following questions: "Do you have a history of liver disease, kidney disease, hepatitis C, history of liver failure, greater than 3 drinks per day or being have you ever been told by your doctor that they should not take acetaminophen"

• History of cardiac arrhythmia

• History of jaundice

• Acute abdominal inflammatory or infectious process at time of surgery

• Known malignancy at time of surgery

• Known pregnancy at time of surgery

• Plan to perform additional significant surgical procedure at the time of hysterectomy such as extensive excision of endometriosis on bowel or bladder or pelvic reconstructive procedure

• >6cm abdominal incision in order to remove the uterus at time of study-related hysterectomy

• Regular use of narcotic pain medication (defined as use on most days of the week at any point in the past 3 months)

• Allergy to acetaminophen

• Women who weigh less than 50 kilograms on the day of surgery.