IV Antibiotics With Lavage for Severe PD Peritonitis

• Status: Completed
• Trial end date: 2018-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized controlled trial to evaluate whether a switch to intravenous antibiotics with adjunctive lavage can improve the outcome of severe peritoneal dialysis related peritonitis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Alice Ho Miu Ling Nethersole Hospital
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Gentamicins; Vancomycin

Criteria

Inclusion Criteria:

• Prevalent PD patients with age >= 18 years old suffering from PD peritonitis

• PD effluent white cell count >1090/mm2 on peritonitis day 3

• Lack of clinical response

• Informed consent available

Exclusion Criteria:

• PD peritonitis in association with exit site or tunnel infection

• Relapsing peritonitis (i.e. peritonitis caused by same organism within 4 weeks after completion of antibiotics therapy)

• Fungal peritonitis

• Mycobacterial peritonitis (both tuberculosis and non-tuberculosis species)

• Clinical suspicion of surgical peritonitis

• Penicillin- or cephalosporin allergy, that cefazolin and ceftazidime could not be used