Overview
IV Iron in Association With Tranexamic Acid for Hip Fracture
Status:
Unknown status
Unknown status
Trial end date:
2016-04-01
2016-04-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
It is a prospective randomized controlled study aiming to test if tranexamic acid combined to intravenous iron before and after surgery for hip fracture in elderly can decrease peri-operative red cell transfusion.Phase:
N/AAccepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Institut Kassab d'OrthopédieTreatments:
Iron
Tranexamic Acid
Criteria
Inclusion Criteria:- Patients undergoing hip fracture surgery within 72 h after trauma.
Exclusion Criteria:
- Vascular events within the last 2 months such as cerebrovascular accident (CVA),
Myocardial infarction (MI), Venous Thromboembolism (VTE) and/or recurrent VTE or
arterial thrombosis.
- Patients receiving anticoagulation therapy with warfarin or clopidogrel.
- History of seizures.
- Multiple fractures.
- Transfusion received during admission, prior to surgery (Hb< 8g/dl).
- Creatinine clearance less than 30 mL/min
- Known history of Factor V Leiden, protein C/S deficiency, prothrombin gene mutation,
anti-thrombin deficiency, anti-phospholipid antibody syndrome, lupus anticoagulant
- Coronary stent placement within the previous 6 months
- Disseminated intravascular coagulation
- Subarachnoid hemorrhage
- Allergy for tranexamic acid
- Hypersensitivity to Iron sucrose or any component of the formulation
- Clinical signs of acute thromboembolic event
- Malignancy
- Body weight > 100kg
- Advanced Dementia