Overview

IV Iron in Association With Tranexamic Acid for Hip Fracture

Status:
Unknown status
Trial end date:
2016-04-01
Target enrollment:
0
Participant gender:
All
Summary
It is a prospective randomized controlled study aiming to test if tranexamic acid combined to intravenous iron before and after surgery for hip fracture in elderly can decrease peri-operative red cell transfusion.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Institut Kassab d'Orthopédie
Treatments:
Iron
Tranexamic Acid
Criteria
Inclusion Criteria:

- Patients undergoing hip fracture surgery within 72 h after trauma.

Exclusion Criteria:

- Vascular events within the last 2 months such as cerebrovascular accident (CVA),
Myocardial infarction (MI), Venous Thromboembolism (VTE) and/or recurrent VTE or
arterial thrombosis.

- Patients receiving anticoagulation therapy with warfarin or clopidogrel.

- History of seizures.

- Multiple fractures.

- Transfusion received during admission, prior to surgery (Hb< 8g/dl).

- Creatinine clearance less than 30 mL/min

- Known history of Factor V Leiden, protein C/S deficiency, prothrombin gene mutation,
anti-thrombin deficiency, anti-phospholipid antibody syndrome, lupus anticoagulant

- Coronary stent placement within the previous 6 months

- Disseminated intravascular coagulation

- Subarachnoid hemorrhage

- Allergy for tranexamic acid

- Hypersensitivity to Iron sucrose or any component of the formulation

- Clinical signs of acute thromboembolic event

- Malignancy

- Body weight > 100kg

- Advanced Dementia