IV vs. Oral Acetaminophen as a Component of Multimodal Analgesia After Total Hip Arthroplasty

• Status: Completed
• Trial end date: 2019-06-16
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine how well two different methods of administrating Tylenol reduce pain and improve patient satisfaction after total hip replacement (THR) surgery. The methods of administration are orally, via a pill that is to be swallowed, and intravenously. Our aim is to determine whether oral or intravenous administration of Tylenol will reduce opioid consumption and opioid-related side effects after THR.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital for Special Surgery, New York
• Collaborator: Mallinckrodt
• Treatments: Acetaminophen

Criteria

Inclusion criteria:

• Adult

• Scheduled for an elective primary THA with a participating surgeon,

• Planned for Combined Spinal Epidural anesthesia (CSE) and Patient Controlled Epidural Analgesia (PCEA)

• English-speaking

• Patients that did not receive pre-operative opioids

Exclusion criteria:

• Hepatic or renal insufficiency, as defined by abnormal readings on liver and kidney functioning tests.

• Hypersensitivity or contraindication to protocol medication

• Contraindication for CSE and PCEA

• Incapable to provide consent/answer questions in English

• Revision or urgent surgery

• Receiving Periarticular Injections

• History of opioid use

• Patients on disability or worker's compensation