Ibuprofen Concentration in Cerebro Spinal Fluid (CSF) of Infants and Children
Status:
Unknown status
Trial end date:
2011-06-01
Target enrollment:
Participant gender:
Summary
Ibuprofen, the active ingredient in Nurofen and Advil, is a commonly used drug in children.
There is very limited data about Ibuprofen concentrations in the cerebro spinal fluid (CSF).
The objective of the current study is to describe concentrations of ibuprofen in the CSF of
infants and children after administration of ibuprofen. We will study infants presenting to
the Emergency Department (ED) with fever who received ibuprofen. A complete sepsis workup
including sampling of blood and CSF is conducted in cases of suspected meningitis. We will
measure ibuprofen in the blood and CSF obtained during the sepsis workup. A better
understanding of the pharmacokinetics of ibuprofen and its penetration into the CSF will
unable us to suggest more accurate dosing guidelines, and to better predict the effects of
this commonly used drug.