Ibuprofen Gel or Capsaicin Cream for my Painful Knee Osteoarthritis?
Status:
Completed
Trial end date:
2018-10-16
Target enrollment:
Participant gender:
Summary
Despite evidence that topical non-steroidal anti-inflammatory drugs (NSAIDs) and capsaicin
are effective in osteoarthritis (OA), it is still unclear why they work for some people but
not others. The investigators are undertaking an individual patient data (IPD) meta-analysis
to identify responders according to patient characteristics, however, no studies report the
presence of synovial hypertrophy or neuropathic-like pain. These two traits are of interest
as they may be used to optimise the treatment effects of the two drugs which work via
different mechanisms to reduce pain in OA. The investigators are therefore conducting this
pilot n-of-1 trial series.
This pilot n-of-1 trial series will investigate whether a person with OA, who has a different
balance between inflammatory and neuropathic pain, shows a preference between these
mechanistically different treatments. The trial will also be used to offer recommendations on
the use of n-of-1 trial series for individualised (precision) medicine in OA.
Phase:
N/A
Details
Lead Sponsor:
University of Nottingham
Collaborators:
Arthritis Research UK Pain Centre Nottingham University Hospitals Charity