Ibuprofen Plus Acetaminophen for Enhanced Pain Reduction
Status:
Not yet recruiting
Trial end date:
2022-03-01
Target enrollment:
Participant gender:
Summary
Combination of analgesics with different modes of action have the potential to offer enhanced
pain relief with reduced dosage. Ibuprofen and acetaminophen have different modes of action.
Combination of ibuprofen and acetaminophen has shown enhanced analgesia in adult studies,
with pediatric data limited to post-operative pain and dental pain. Our study objective is to
evaluate the analgesic efficacy of oral acetaminophen plus ibuprofen versus ibuprofen plus
placebo for the management of acute pain in a pediatric emergency department.