Ibuprofen Supplementation After Resistance Training and Its Effects on Bone in Older Women

• Status: Completed
• Trial end date: 2014-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

Inflammation increases with aging and is implicated in the reduction of bone mass, muscle mass, and strength. Resistance training is safe and effective for increasing muscle mass and strength in older adults,however resistance training by itself cannot suppress inflammation. Ibuprofen is a non-steroidal anti-inflammatory drug that may provide benefits to muscle mass and strength when given after resistance training sessions in older adults; however, more evidence is required to confirm effects across the lifespan. The objectives are to determine the effect of 9 months of exercise training and ibuprofen supplementation, compared to placebo, in older women (≥65years)on the following dependent variables:

• bone density, geometry, and architecture

• muscle mass and strength

• balance

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Saskatchewan
• Collaborator: Canadian Institutes of Health Research (CIHR)
• Treatments: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Ibuprofen

Criteria

Inclusion Criteria:

• women >65yrs

Exclusion Criteria:

• high risk of fracture

• use of bisphosphonates, hormone replacement therapy, selective estrogen receptor modulators, PTH, or calcitonin within the past 12 months

• taking medications that affect bone mineral metabolism

• have diseases that are known to affect bone mineral metabolism

• have severe osteoarthritis

• currently a smoker

• currently participating in moderate-vigorous resistance-exercise training more than once per week