Ibuprofen Treatment of Hemodynamically Significant Patent Ductus Arteriosus (hsPDA) in Preterm Infants
Status:
Not yet recruiting
Trial end date:
2023-06-01
Target enrollment:
Participant gender:
Summary
Babies who are born very prematurely are often born with murmurs in the heart. In preterm
babies, one of the most common causes of murmur is the presence of a PDA. This is the
persistence of a connection that normally exists in the baby before it is born, connecting
between the major blood vessels that leave the heart. In term babies, this channel closes
shortly after birth when normal adult circulation is achieved. However, in preterm babies,
the PDA can remain open, which can lead to multiple problems in the baby.
Our current standard of treatment in the Neonatal Intensive Care Unit (NICU) is to perform
cardiac ultrasound (echocardiogram) in all babies less than 29 weeks gestation to diagnose
the presence of hsPDA. We also use an echocardiogram to follow the PDA until complete close.
If present, the standard treatment in the NICU is to give medication, usually Ibuprofen, a
non-steroidal anti-inflammatory drugs (NSAID), to close the PDA.
Near-infrared spectroscopy (NIRS) is a new type of device to detect oxygenated blood supply
to the brain, kidney, and abdominal regions, which can detect a gastro disease called
Necrotizing enterocolitis (NEC). This device is used to assess the effects of Ibuprofen on
oxygen supply to these three regions.