Ibuprofen Versus Indomethacin Following Emergent Cerclage Placement
Status:
Recruiting
Trial end date:
2024-06-01
Target enrollment:
Participant gender:
Summary
Cervical insufficiency is defined as painless cervical dilation in the second trimester.
Cervical insufficiency can ultimately lead to second trimester loss of pregnancy. Cerclages
are utilized in pregnancies affected by cervical insufficiency in order to prolong
gestational latency. There have been several studies investigating the efficacy of
perioperative medications for cerclage placement and the effects they have on gestational
latency. Some such studies have found that perioperative indomethacin in combination with
antibiotics have significantly increased gestational latency when compared to placebo.
Indomethacin has traditionally been the tocolytic of choice with cerclage placement. At our
hospital, ibuprofen has been the tocolytic of choice for cerclage placement secondary to
pharmacy availability. Our study aims to evaluate whether gestational latency differs among
patients undergoing emergent cerclage whether they receive perioperative ibuprofen or
indomethacin.