Ibuprofen Versus Mecillinam for Uncomplicated Cystitis

• Status: Completed
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

Although uncomplicated cystitis is considered to be a mild condition and mostly self limiting, most patients who see a doctor will be treated with antibiotics. Antibiotics are known to give a quick relief of symptoms and shorten the course of the condition by a few days. The aim of this study is to evaluate ibuprofen versus mecillinam in the treatment of uncomplicated cystitis in otherwise healthy, non-pregnant women. Our main objective is to see whether symptomatic treatment with ibuprofen is equally efficient as treatment with mecillinam in this group.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oslo
• Collaborators: Lund University; University of Bergen; University of Copenhagen
• Treatments: Amdinocillin; Ibuprofen

Criteria

Inclusion Criteria:

• woman between 18 and 60 years of age

• dysuria and pollakiuria and/or urinary urgency

• ability to give written consent

Exclusion Criteria:

• pregnancy/breastfeeding child under one month of age

• diabetes

• kidney disease

• organic aciduria

• clinical suspicion of pyelonephritis; fever, reduced general condition, upper back pain

• vaginal symptoms such as discharge or irritation

• severe abdominal pain

• symptoms that have lasted for more than seven days

• one or more urinary tract infections within the lasts four weeks

• permanent bladder catheter or use of bladder catheter within the last four weeks

• use of antibiotics within the last two weeks

• participated in a clinical trial within the last four weeks

• previously undergone a pyelonephritis

• previous allergic reaction to penicillin

• previous allergic reaction to ibuprofen, or worsening of asthma when using nonsteroidal antiinflammatory drugs(NSAIDs)

• narrow oesophagus

• use of the drug probenecid

• severe gastritis or previous ulcer

• anticoagulative treatment

• ongoing use of steroids

• use of immunosuppressant drugs

• thrombocytopenia,

• Chrohn's disease or Ulcerative colitis

• heart insufficiency

• severe psychiatric illness or dementia

• severe drug addiction

• unable to communicate in Norwegian, Swedish or Danish language