Ibuprofen vs Dipyrone After C-section in Preeclampsia

• Status: Not yet recruiting
• Trial end date: 2023-01-31
• Target enrollment: 0
• Participant gender: Female

Summary

The goal of this randomized, triple-masked clinical trial is to compare the effectiveness and safety of the use of ibuprofen versus dipyrone for postoperative analgesia in postpartum women with preeclampsia undergoing cesarean section.

The main question it aims to answer are:

• Postoperative pain is similar;

• The frequency of acute kidney injury is similar.

Researchers will compare one group that will receive dipyrone and the other group that will receive ibuprofen to see if Postoperative pain are different between groups or development of acute kidney injury each group is different.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto Materno Infantil Prof. Fernando Figueira
• Treatments: Dipyrone; Ibuprofen

Criteria

Inclusion Criteria:

• Puerperal women from 14 years of age diagnosed with preeclampsia with signs of severity Immediate postoperative period;

• Delivery attended at the Maternity from Instituto de Medicina Integral Prof Fernando Figueira.

Exclusion Criteria:

• Acute kidney disease (serum creatinine 1.5 to 1.9 times baseline, or increase in serum creatinine by ≥0.3 mg/dL, or decrease in urine output to <0.5 mL/kg/hour for six to 12 hours)

• Chronic kidney disease;

• Diabetes mellitus;

• Collagenoses;

• Sickle cell anemia;

• Patients who presented bleeding in the pre, trans and immediate postpartum periods;

• Antepartum or puerperal sepsis;

• Known contraindications to the use of NSAIDs and dipyrone;