Ictal SPECT With Intra-arterial Injection

• Status: Withdrawn
• Trial end date: 2018-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Ictal SPECT with intravenous injection in a cubital vein of a perfusion tracer is an established technique to localize the ictal onset zone during presurgical evaluation of refractory focal epilepsy. When seizures last less than 10 seconds, localizing information is often not obtained. Since it takes around 30 seconds before the tracer reaches the brain after intravenous injection, ictal hyperperfusion most likely has already switched to postictal hypoperfusion. In this study, we plan to inject the perfusion tracer in the aorta proximal to the cerebral arteries, which will allow a true ictal injection in patients with seizures of short duration.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universitaire Ziekenhuizen Leuven

Criteria

Inclusion Criteria:

• Refractory unifocal epilepsy

• Early ictal SPECT with intravenous injection did not localize the ictal onset zone

• Several seizure per day, or clusters of several seizures per day

• Seizures are of short duration (i.e. less than 10-15 seconds)

• Patient asks for epilepsy surgery

Exclusion Criteria:

• Renal failure

• Allergy to contrast agents

• Fever

• Anemia

• Usage of anticoagulants

• Pregnancy