Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)
Status:
Not yet recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the
posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology,
prosocial behavior and sexual function. Hypopituitarism is associated with increased obesity,
increased psychopathology, sexual and prosocial dysfunction despite appropriate hormone
replacement. A few studies suggest the existence of a possible OT deficient state in
hypopituitarism. In animal models, glucagon-like peptide 1 (GLP1) has shown to increase OT
release.
This study is designed to evaluate OT values after administration of GLP1 in adults (healthy
volunteers and patients with hypopituitarism).
The investigators hypothesize that OT response will be blunted following GLP1 receptor
agonist (GLP1-RA) in patients with hypopituitarism compared to healthy controls.
Phase:
Phase 4
Details
Lead Sponsor:
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau