Identification of Multi-modal Bio-markers for Early Diagnosis and Treatment Prediction in Schizophrenia Individuals

• Status: Unknown status
• Trial end date: 2020-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to screen and validate multi-scale bio-markers for early diagnosis and medication monitoring for early schizophrenia, including the genetic, neurobiochemistry, neuroimaging and eletrophysiological measures. Based on the validated bio-markers, the present study further tries to build several prediction models for early differential diagnosis of schizophrenia from healthy controls and other mental diseases (such as the major depression and anxiety disorders), biological sub-typing and diagnosis of the schizophrenia sub-types, and early prediction of the medication effects.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tianjin Medical University General Hospital
• Collaborators: Anhui Mental Health Center; First Affiliated Hospital of Chongqing Medical University; First Affiliated Hospital of Harbin Medical University; Harbin First Specialist Hospital; Nanjing Brain Hospital Affiliated to Nanjing Medical University; Nanjing Medical University; Shanghai Mental Health Center; Tianjin Anding Hospital; Wenzhou Seventh People's Hospital; Wuhan Psychiatric Hospital
• Treatments: Aripiprazole; Olanzapine; Risperidone

Criteria

Inclusion Criteria for patients:

• According with American mental disorder diagnosis and Diagnostic criteria for schizophrenia, major depressive disorder, and anxiety disorder in the statistical manual DSM-IV

• The time from the onset of symptoms for the first time to participate in study is less than 12 months

• No any anti-psychotic drugs or medication was taken more than 14 days

• Han nationality

• 18 to 45 years old

• Right-handed

Inclusion Criteria for healthy controls:

• Han nationality

• Right-handedness

• Gender, age and education level are matched with patients

• 18 to 45 years old

• Any mental disorder diagnosis in DSM-IV was excluded

• There were no relatives with severe mental disorder in the two or three generations

Exclusion Criteria:

• The patient has other psychiatric disorder beside the illness

• A history of psychoactive substance use, accompanied by severe physical disease

• Have a history of epilepsy or coma

• Women who are pregnant or breast-feeding

• Accompanied by metal implants, claustrophobia and other contraindications of MRI scan