Identifocation the B Cell Subsets Responsible for Anti-pneumococcal Response

• Status: Completed
• Trial end date: 2016-04-05
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to determine which B lymphocytes subsets are responsible for the production of IgM, IgG2 and IgA anti-pneumococcal capsular polysaccharides after vaccination with a 23-valent pneumococcal polysaccharide vaccine.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
• Treatments: Heptavalent Pneumococcal Conjugate Vaccine; Vaccines

Criteria

Inclusion Criteria:

• male

• aged 18 to 40 y

Exclusion Criteria:

• no documented primary immunodeficiency

• no splenectomy

• no functional/congenital asplenia,

• no pneumococcal infections within the last 5 years before enrolment into the research protocol

• no vaccinations with the 23-valent pneumococcal polysaccharide vaccine or the 7- or 13-valent conjugate-polysaccharide vaccines within the last 5 years before enrolment into the research protocol

• no other vaccination within 1 month before enrolment into the research protocol

• fever, current antibiotic treatment

• any chronic or inflammatory disease

• any immunosuppressive treatment

• hyper-responsiveness to one component of the Pneumovax vaccine