Identifying Factors That Predict Antidepressant Treatment Response

• Status: Completed
• Trial end date: 2015-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will compare different treatments for depression in order to identify which factors predict effectiveness, and will include a companion study which investigates combining treatments and long term effectiveness.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Emory University
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Antidepressive Agents; Citalopram; Dexetimide; Duloxetine Hydrochloride

Criteria

Inclusion Criteria:

• Current DSM-IV diagnosis of major depressive episode, as determined by Structured Clinical Interview for DSM-IV (SCID-IV)

• Primary diagnosis of MDD, based on prominence of symptoms and target for intervention (comorbid anxiety disorders, except obsessive-compulsive disorder (OCD), will not be criteria for exclusion)

• Score of at least 18 on the 17-item Hamilton Rating Scale for Depression (HAM-D17)

• Agrees to use an effective form of contraception and/or double barrier method

Exclusion Criteria:

• Previously treated for major depression with either medication or psychotherapy

• Current psychosis, dementia, eating disorder, or dissociative disorder

• History of bipolar disorder (I and II) or schizophrenia

• Alcohol or drug dependence within 3 months prior to study entry or current alcohol or drug abuse (excluding nicotine and caffeine), as assessed by medical history and urine drug screening

• Requires neuroleptic or mood stabilizer therapy in addition to depression treatment

• Presence of any acute or chronic medical disorder that could affect successful completion of the trial

• Medical contraindications that would preclude treatment with escitalopram or duloxetine

• Presence of practical issues that would likely prevent completion of the study (e.g., planned geographical relocation)

• Pregnant or breastfeeding

• Medical conditions that could prevent the safe use of MRI (e.g., pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, or other implants; steel worker)

• Medical conditions that could prevent the safe completion of a dexamethasone-corticotropin releasing factor (Dex-CRF) test (e.g., uncontrolled hypertension, significant abnormalities in EKG, anemia, known allergies against drugs)