Overview

Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma

Status:
Unknown status

Trial end date:
1969-12-31

Target enrollment:

Participant gender:

Summary

RATIONALE: Drugs used in chemotherapy, such as ifosfamide and doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving combination chemotherapy with or without radiation therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving radiation therapy after surgery may kill any tumor cells that remain after surgery. PURPOSE: This phase III trial is studying how well giving ifosfamide and doxorubicin, radiation therapy, and/or surgery works in treating young patients with localized soft tissue sarcoma.

Phase:

Phase 3

Details

Lead Sponsor:

European Paediatric Soft Tissue Sarcoma Study Group

Collaborators:

Children's Cancer and Leukaemia Group
Cooperative Weichteilsarkom Studie
Dutch Childhood Oncology Group
Italian Association for Pediatric Hematology Oncology

Treatments:

Doxorubicin
Ifosfamide
Isophosphamide mustard
Liposomal doxorubicin