Image Guided IMRT, Radiochemotherapy and MRI-based IGABT in Locally Advanced Cervical Cancer
Status:
Recruiting
Trial end date:
2031-04-01
Target enrollment:
Participant gender:
Summary
The research group on adaptive image-guided radiotherapy for locally advanced cervical
carcinoma completed the protocol for the EMBRACE II study in October 2018. This study will be
carried out in the next few years at the University Clinic for Radiotherapy at the Medical
University of Vienna and other international partner institutes. EMBRACE II builds on the
findings of the current EMBRACE study. These are already implemented in everyday clinical
practice in order to further improve the accuracy of the entire therapy of cervical
carcinomas, using state-of-the-art techniques of tele- and brachytherapy. The aim of the
EMBRACE II study is to maintain and enhance the excellent local tumor control as well as the
nodal and systemic control for all tumor stages while minimizing the adverse reaction rates
for all affected organs (rectum, sigmoid, urinary bladder, and vagina) to increase the
quality of life of patients with cervical carcinomas.
Phase:
Phase 2
Details
Lead Sponsor:
Medical University of Vienna
Collaborators:
Aarhus Universitetshospital Academisch Medisch Centrum (AMC) Amsterdam Addenbrooke's NHS Trust Cambridge Antoni van Leeuwenhoekziekenhuis (AVL) Amsterdam Bristol Haematology & Oncology Centre Catharina Ziekenhuis Eindhoven Chulalongkorn University Bangkok Clinic Hospital Universitari Barcelona Complejo Hospitalario de Navarra Cross Cancer Institute Edmonton Erasmus University Medical Center Rotterdam Fondazione IRCCS Istituto Nazionale dei Tumori, Milano Guy's and St Thomas' NHS Foundation Trust London Hôpital Maisonneuve-Rosemont Montréal Institut Bergonié Bordeaux Institut Català d'Oncologia (ICO) Barcelona Institute Gustave Roussy Paris Institute of Oncology Ljubljana Klinikum der Universität München - Campus Großhadern/Innenstadt Leeds Teaching Hospitals NHS Trust Leiden University Medical Center (LUMC) Liverpool Hospital, Sydney Loyola University Chicago Maastro Maastricht McGill University MD Anderson Cancer Center University of Texas Mount Vernon Cancer Centre - East & North Hertfordshire NHS Trust London National Cancer Institute Bratislava North Estonia Medical Centre Foundation Tallinn Odense Universitetshospital Pamela Youde Nethersole Eastern Hospital, Hong Kong Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh Princess Margaret Cancer Centre Toronto Radboudumc Nijmegen Radiotherapiegroep Region Örebro County Rigshospitalet, Denmark Royal Marsden Hospital London Siriraj Piyamaharajkarun Hospital Bangkok Skåne University Hospital Lund Tata Memorial Center Mumbai The Christie NHS Foundation Trust Manchester The Norwegian Radiumhospital - Oslo University Hospital HF Tom Baker Cancer Center Calgary Tuen Mun Hospital Hong Kong UMC Utrecht Cancer Center University Hospital Coventry & Warwickshire Coventry University Hospital Heidelberg UPMC Hillman Cancer Center Pittsbrugh UZ Leuven