Imaging Biomarkers of Pancreatic Function and Disease
Status:
Enrolling by invitation
Trial end date:
2027-12-01
Target enrollment:
Participant gender:
Summary
This study seeks to understand the performance of MRI to characterize pancreatitis and
predict chronic complications (endocrine and exocrine) of pancreatitis. Through multiple
aims, the investigators will benchmark MRI against relevant reference standards (e.g.
endoscopic pancreatic function tests, laboratory data). The investigators will also
characterize repeatability of the imaging findings and will work to develop methods to
simplify and automate analysis of the MRI images.
Research interventions depend on the Aim(s) participants enroll in but include: endoscopic
pancreatic function testing (added on to clinically indicated upper GI endoscopy), blood
tests, stool tests, gene sequencing, and survey completion. All participants will undergo
research MRI examinations, a subset of which will include administration of intravenous
secretin.
Phase:
Phase 4
Details
Lead Sponsor:
Children's Hospital Medical Center, Cincinnati
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)