Imaging Kidney Transplant Rejection Using Ferumoxytol-Enhanced Magnetic Resonance

• Status: Completed
• Trial end date: 2017-04-11
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to develop a non-invasive imaging test for in vivo detection of kidney transplant rejection. The hypotheses are that 1) Ferumoxytol-MRI can generate accurate estimates of tissue iron concentrations and tissue macrophages. 2) The signal given by a renal allograft on Ferumoxytol-MRI demonstrates significant differences between rejected and non-rejected transplants.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Stanford University
• Collaborator: Lucile Packard Children's Hospital
• Treatments: Ferrosoferric Oxide

Criteria

Inclusion Criteria:

• Completed solid organ transplant with referral for transplant follow-up

Exclusion Criteria:

• Exclusion criteria comprise MR-incompatible metal implants, need of sedation (since an anesthesia is not supported by this), claustrophobia or hemosiderosis/hemochromatosis.