Imaging Procedure Using ALA in Finding Residual Tumor in Grade IV Malignant Astrocytoma
Status:
Completed
Trial end date:
2018-10-14
Target enrollment:
Participant gender:
Summary
RATIONALE: Imaging procedures that use aminolevulinic acid (ALA) may help find and diagnose
residual tumor in participants with grade IV malignant astrocytoma who are undergoing surgery
to remove the tumor.
PURPOSE: Our primary long-term goal is to improve the completeness of surgical resection of
malignant brain tumor through image- guided fluorescence localization. We hypothesize that
the use of qualitative fluorescence imaging and point PpIX concentration quantification will
enable more complete tumor resection than normal direct (i.e., white light) visualization,
and thereby improve participant survival.